si-544 – A Highly Differentiated Asset in Autoimmunity

  • Best-in-class Kv1.3 blocker

  • Benchmark for safety and tolerability in autoimmune therapy

  • Maintains patient’s full immunocompetence

  • Short treatment course delivers sustained clinical benefit

  • Pipeline drug for autoimmunity

Our Goal

To improve quality of life for patients by developing best-in-class ion channel blockers.

Our Technology

A highly efficient screening and development platform to identify and optimize the most targeted peptides for our drug development.

News & Events

News

selectION Demonstrates Safety and Disease-Modifying Mechanism of Action of its Investigational Drug, si-544, in Phase 1b Proof-of- Concept Trial in Psoriasis, a T Cell-Mediated Autoimmune Disease

San Diego, CA, USA, and Munich, Germany – October 21, 2025 – selectION, Inc. (“selectION” or the “Company”), a clinical-stage biopharmaceutical company developing novel treatments for T cell-mediated autoimmune diseases, today announced the successful completion of its phase 1b proof-of-concept trial evaluating si-544, a first-in-class Kv1.3 blocker in patients diagnosed with psoriasis vulgaris.

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